Active Ingredient: Avelumab
Avelumab is indicated as monotherapy for the treatment of adult patients with metastatic Merkel cell carcinoma (MCC).
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
10 - 10 mg per kg of body weight
From 10 To 10 mg per kg of body weight once every 14 day(s)
The recommended dose of avelumab is 10 mg/kg body weight administered intravenously over 60 minutes every 2 weeks.
Administration of avelumab should continue according to the recommended schedule until disease progression or unacceptable toxicity. Patients with radiological disease progression not associated with significant clinical deterioration, defined as no new or worsening symptoms, no change in performance status for greater than two weeks, and no need for salvage therapy, could continue treatment.
Patients have to be premedicated with an antihistamine and with paracetamol prior to the first 4 infusions of avelumab. If the fourth infusion is completed without an infusion-related reaction, premedication for subsequent doses should be administered at the discretion of the physician.
Intravenously over 60 minutes.
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