Relapsing multiple sclerosis (RMS)

Active Ingredient: Daclizumab

Indication for Daclizumab

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Daclizumab is indicated for the treatment of adult patients with relapsing forms of multiple sclerosis (RMS) who have had an inadequate response to at least two disease modifying therapies (DMTs) and for whom treatment with any other DMT is contraindicated or otherwise unsuitable.

For this indication, competent medicine agencies globally authorize below treatments:

150 mg once a month


Dosage regimens

Subcutaneous, 150 milligrams daclizumab, once monthly.

Detailed description

The recommended dose of daclizumab beta is 150 mg injected subcutaneously once a month.

In case a dose is missed and it is within 2 weeks of the missed dose, patients should be instructed to inject without delay their missed dose and then remain on their original monthly dosing schedule.

If a dose is missed and it is more than 2 weeks from the missed dose, patients should skip the missed dose, wait until their next scheduled dose, and then remain on their original monthly dosing schedule.

Only one dose should be administered at a time to make up for a missed dose.

Dosage considerations

The usual sites for subcutaneous injection include the thigh, abdomen, and back of the upper arm.

Active ingredient


Daclizumab beta is a humanised IgG1 monoclonal antibody that binds to CD25 (IL-2RĪ±), and prevents IL-2 binding to CD25, resulting in higher levels of IL-2 available for signalling through the intermediate-affinity IL-2 receptor. Key effects of this IL-2 pathway modulation potentially related to the therapeutic effects of daclizumab beta in MS include selective antagonism of activated T-cell responses, and expansion of immunoregulatory CD56bright natural killer (NK) cells, which have been shown to selectively decrease activated T-cells.

Read more about Daclizumab

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