External genital and perianal warts (condylomata acuminata)

Active Ingredient: Imiquimod

Indication for Imiquimod

Population group: only adults (18 years old or older)

Imiquimod cream is indicated for the topical treatment of external genital and perianal warts (condylomata acuminata) in adults.

For this indication, competent medicine agencies globally authorize below treatments:

1 spread once every other day

Route of admnistration


Defined daily dose

1 - 1 {spreads}

Dosage regimen

From 1 To 1 {spreads} once every 2 day(s)

Detailed description

Imiquimod cream should be applied 3 times per week (example: Monday, Wednesday, and Friday; or Tuesday, Thursday, and Saturday) prior to normal sleeping hours, and should remain on the skin for 6 to 10 hours. Imiquimod cream treatment should continue until the clearance of visible genital or perianal warts or for a maximum of 16 weeks per episode of warts.

Dosage considerations

Imiquimod cream should be applied in a thin layer and rubbed on the clean wart area until the cream vanishes. Only apply to affected areas and avoid any application on internal surfaces. Imiquimod cream should be applied prior to normal sleeping hours. During the 6 to 10 hour treatment period, showering or bathing should be avoided. After this period it is essential that imiquimod cream is removed with mild soap and water. Application of an excess of cream or prolonged contact with the skin may result in a severe application site reaction. A single-use sachet is sufficient to cover a wart area of 20 cm² (approx. 3 inches2). Sachets should not be re-used once opened. Hands should be washed carefully before and after application of cream.

Uncircumcised males treating warts under the foreskin should retract the foreskin and wash the area daily.

Active ingredient


Imiquimod is an immune response modifier. Saturable binding studies suggest a membrane receptor for imiquimod exists on responding immune cells. Imiquimod has no direct antiviral activity.

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