Hereditary angioedema (HAE)

Active Ingredient: C1-inhibitor

Indication for C1-inhibitor

Population group: only children (1 year - 12 years old)

Treatment and pre-procedure prevention of angioedema attacks in adults, adolescents and children (2 years old and above) with hereditary angioedema (HAE).

For this indication, competent medicine agencies globally authorize below treatments:

500-1,000 IU once

Route of admnistration

Intravenous

Defined daily dose

500 - 1,000 [iU]

Dosage regimen

From 500 To 1,000 [iU] once every day

Detailed description

2 to 11 years, >25 kg: 1,000 IU of C1-inhibitor at the first sign of the onset of an acute attack. A second dose of 1,000 IU may be administered if the patient has not responded adequately after 60 minutes.

2 to 11 years, 10-25 kg: 500 IU of C1-inhibitor at the first sign of the onset of an acute attack. A second dose of 500 IU may be administered if the patient has not responded adequately after 60 minutes.

Active ingredient

C1-inhibitor

C1 inhibitor is a single chain glycoprotein found in plasma and a member of the serine protease inhibitor, or serpin, superfamily of proteins. C1 inhibitor inhibits the complement system by binding C1r and C1s and is the most important inhibitor of contact activation, regulating the contact system and the intrinsic coagulation pathway by binding to and inactivating kallikrein and factor XIIa.

Read more about C1-inhibitor

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