Psoriatic arthritis

Active Ingredient: Etanercept

Indication for Etanercept

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Treatment of active and progressive psoriatic arthritis in adults when the response to previous diseasemodifying antirheumatic drug therapy has been inadequate. Etanercept has been shown to improve physical function in patients with psoriatic arthritis, and to reduce the rate of progression of peripheral joint damage as measured by X-ray in patients with polyarticular symmetrical subtypes of the disease.

For this indication, competent medicine agencies globally authorize below treatments:

25 mg twice weekly or 50 mg once week

For:

Dosage regimens

Regimen A: Subcutaneous, 25 milligrams etanercept, 2 times weekly.

Regimen B: Subcutaneous, 50 milligrams etanercept, once weekly.

Detailed description

25 mg etanercept administered twice weekly is the recommended dose. Alternatively, 50 mg administered once weekly has been shown to be safe and effective.

Available data suggest that a clinical response is usually achieved within 12 weeks of treatment. Continued therapy should be carefully reconsidered in a patient not responding within this time period.

Active ingredient

Etanercept

Etanercept is a competitive inhibitor of TNF binding to its cell surface receptors, and thereby inhibits the biological activity of TNF. The mechanism of action of etanercept is thought to be its competitive inhibition of TNF binding to cell surface TNFR, preventing TNF-mediated cellular responses by rendering TNF biologically inactive.

Read more about Etanercept

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