Interferon beta-1b is indicated for the treatment of:
For this indication, competent medicine agencies globally authorize below treatments:
62.5 - 250 ug
From 62.5 To 250 ug once every 2 day(s)
The recommended dose of interferon beta 1b is 250 microgram, to be injected subcutaneously every other day.
Generally, dose titration is recommended at the start of treatment.
Patients should be started at 62.5 microgram subcutaneously every other day, and increased slowly to a dose of 250 microgram every other day (see Table A). The titration period may be adjusted, if any significant adverse reaction occurs. In order to obtain adequate efficacy, a dose of 250 microgram every other day should be reached.
Table A. Schedule for dose titration*:
|1, 3, 5||62.5 microgram|
|7, 9, 11||125 microgram|
|13, 15, 17||187.5 microgram|
* The titration period may be adjusted if any significant adverse reaction occurs.
The optimal dose has not been fully clarified.
At the present time, it is not known for how long the patient should be treated. There are follow-up data under controlled clinical conditions for patients with relapsing-remitting multiple sclerosis for up to 5 years and for patients with secondary progressive multiple sclerosis for up to 3 years. For relapsing-remitting multiple sclerosis, efficacy has been demonstrated for therapy for the first two years. The available data for the additional three years are consistent with sustained treatment efficacy of interferon beta 1b over the whole time period.
In patients with a single clinical event suggestive of multiple sclerosis, efficacy has been demonstrated over a period of three years.
Treatment is not recommended in patients with relapsing-remitting multiple sclerosis who have experienced less than 2 relapses in the previous 2 years or in patients with secondary-progressive multiple sclerosis who have had no active disease in the previous 2 years.
If the patient fails to respond, for example a steady progression in Expanded Disability Status Scale (EDSS) for 6 months occurs or treatment with at least 3 courses of adrenocorticotropic hormone (ACTH) or corticosteroids during a one-year period is required despite interferon beta 1b therapy, treatment with interferon beta 1b should be stopped.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.