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Active Ingredient: Spiramycin

Indication for Spiramycin

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

For this indication, competent medicine agencies globally authorize below treatments:

150,000-300,000 IU/kg in 2-3 divided doses daily

Route of admnistration

Oral

Defined daily dose

150,000 - 300,000 [iU] per kg of body weight

Dosage regimen

From 50,000 To 100,000 [iU] per kg of body weight 3 time(s) per day every day

Detailed description

1.5 to 3 million IU per 10 kg of body weight per day in 2 to 3 intakes.

Active ingredient

Spiramycin

Antibacterial antibiotic belonging to the macrolides family. Spiramycin inhibits translocation by binding to bacterial 50S ribosomal subunits with an apparent 1:1 stoichiometry. This antibiotic is a potent inhibitor of the binding to the ribosome of both donor and acceptor substrates. Spiramycin induces rapid breakdown of polyribosomes, an effect which has formerly been interpreted as occurring by normal ribosomal run-off followed by an antibiotic-induced block at or shortly after initiation of a new peptide.

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