HIV-1 infection

Active Ingredient: Fosamprenavir

Indication for Fosamprenavir

Population group: only children (1 year - 12 years old)

Fosamprenavir in combination with low dose ritonavir is indicated for the treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infected children of 6 years and above in combination with other antiretroviral medicinal products.

For this indication, competent medicine agencies globally authorize below treatments:

36 mg/kg in 2 divided doses daily

Route of admnistration


Defined daily dose

36 - 36 mg per kg of body weight

Dosage regimen

From 18 To 18 mg per kg of body weight 2 time(s) per day every day

Detailed description

Dosing recommendations for fosamprenavir with ritonavir:

AgeBody weightFosamprenavir dose (TWICE DAILY) Ritonavir dose (TWICE DAILY)
Adult (≥18 years)  Tablet or Oral suspension 700 mg (1 tablet or 14 ml suspension)Capsule or Solution 100 mg
Oral suspension should be taken without food.
6-17 years≥39 kgTablet or Oral suspension 700 mg (1 tablet or 14 ml suspension)Capsule or Solution 100 mg
Oral suspension should be taken with food.
33-38 kgOral suspension 18 mg/kg (0.36 ml/kg); maximum 700 mg or 14 mlCapsule or Solution 100 mg
Oral suspension should be taken with food.
25-32 kgOral suspension 18 mg/kg (0.36 ml/kg)Solution 3 mg/kg
Oral suspension should be taken with food.
<25 kgNo dosing recommendations. 
<6 years Not recommended. 

Dosage considerations

Fosamprenavir can be taken with or without food.

Active ingredient


Fosamprenavir after oral administration, is rapidly and almost completely hydrolysed to amprenavir and inorganic phosphate prior to reaching the systemic circulation. Amprenavir binds to the active site of HIV-1 protease and thereby prevents the processing of viral gag and gag-pol polyprotein precursors, resulting in the formation of immature noninfectious viral particles.

Read more about Fosamprenavir

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