Metastatic breast cancer

Active Ingredient: Bevacizumab

Indication for Bevacizumab

Population group: only adults (18 years old or older)
Therapeutic intent: Adjunct intent

Bevacizumab in combination with paclitaxel is indicated for first-line treatment of adult patients with metastatic breast cancer.

Bevacizumab in combination with capecitabine is indicated for first-line treatment of adult patients with metastatic breast cancer in whom treatment with other chemotherapy options including taxanes or anthracyclines is not considered appropriate. Patients who have received taxane and anthracycline-containing regimens in the adjuvant setting within the last 12 months should be excluded from treatment with bevacizumab in combination with capecitabine.

For this indication, competent medicine agencies globally authorize below treatments:

10 mg/kg of body weight once every 2 weeks or 15 mg/kg of body weight once every 3 weeks


Dosage regimens

Regimen A: Intravenous, 10 milligrams bevacizumab per kilogram of body weight, once every 2 weeks.

Regimen B: Intravenous, 15 milligrams bevacizumab per kilogram of body weight, once every 3 weeks.

Detailed description

The recommended dose of bevacizumab is 10 mg/kg of body weight given once every 2 weeks or 15 mg/kg of body weight given once every 3 weeks as an intravenous infusion.

It is recommended that treatment be continued until progression of the underlying disease or until unacceptable toxicity.

Dosage considerations

It should not be administered as an intravenous push or bolus.

Dose reduction for adverse reactions is not recommended. If indicated, therapy should either be permanently discontinued or temporarily suspended.

Active ingredient


Bevacizumab binds to vascular endothelial growth factor (VEGF), the key driver of vasculogenesis and angiogenesis, and thereby inhibits the binding of VEGF to its receptors, Flt-1 (VEGFR-1) and KDR (VEGFR-2), on the surface of endothelial cells. Neutralising the biological activity of VEGF regresses the vascularisation of tumours, normalises remaining tumour vasculature, and inhibits the formation of new tumour vasculature, thereby inhibiting tumour growth.

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