Impetigo

Active Ingredient: Retapamulin

Indication for Retapamulin

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

Treatment

Route of admnistration

Cutaneous

Defined daily dose

2 {spreads}

Dosage regimen

1 {spreads} 2 time(s) per day every day for 5 day(s)

2 spreads in 2 divided doses daily

Route of admnistration

Cutaneous

Defined daily dose

2 - 2 {spreads}

Dosage regimen

From 1 To 1 {spreads} 2 time(s) per day every day

Detailed description

A thin layer of ointment should be applied to the affected area twice daily for five days.

The area treated may be covered with sterile bandage or gauze dressing.

Safety and efficacy have not been established in the following:

  • Impetiginous lesions >10 in number and exceeding 100 cm2 in total surface area.
  • Infected lesions that exceed 10 cm in length or a total surface area >100 cm2.

In patients aged less than 18 years the total surface area treated should be no more than 2% of the body surface area.

Patients not showing a clinical response within two to three days should be re-evaluated and alternative therapy should be considered.

Active ingredient

Retapamulin

Retapamulin is a semi-synthetic derivative of the compound pleuromutilin, which is isolated through fermentation from Clitopilus passeckerianus. Retapamulin selectively inhibits bacterial protein synthesis by interacting at a unique site on the 50S subunit of the bacterial ribosome that is distinct from the binding sites of other non-pleuromutilin antibacterial agents that interact with the ribosome.

Read more about Retapamulin

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