Benzodiazepines are only indicated when the disorder is severe, disabling or subjecting the individual to extreme distress.
For this indication, competent medicine agencies globally authorize below treatments:
For: Elders (65+)
Oral, 125 micrograms, once daily at the end of the day.
In the elderly, debilitated or patients with impaired hepatic function initial dosage should be 125 micrograms (0.125 mg) to decrease the possibility of development of over sedation, dizziness, or impaired coordination. It is seldom necessary to exceed that dose.
Triazolam should be taken just before going to bed.
For: Adults (18-64)
Oral, between 125 and 250 micrograms, once daily at the end of the day.
Treatment should be as short as possible. Generally the duration of treatment varies from a few days to two weeks with a maximum, including tapering-off process, of four weeks.
Dosage should be adjusted on the basis of the individual patient response to achieve effect without overdosage. The lowest effective dose should be used. In patients previously untreated with hypnotics, initial dosage should be 125 micrograms (0.125 mg). A maximum dose of 250 micrograms (0.25 mg) should not be exceeded because of risk of unacceptable CNS adverse effects.
Patients with renal impairment may be administered triazolam in the usual dose range; as appropriate.
Triazolam is not recommended for use in children and adolescents below the age of 18 years due to insufficient data on safety and efficacy.
In certain cases extension beyond the maximum treatment period may be necessary; if so, it should not take place without re-evaluation of the patient’s status.
Treatment should be started with the lowest recommended dose. The maximum dose should not be exceeded.
Triazolam should be taken just before going to bed. The usual dose is 250 micrograms (0.25 mg) at night.
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