Wilson's disease

Active Ingredient: Zinc

Indication for Zinc

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Treatment of Wilson’s disease.

For this indication, competent medicine agencies globally authorize below treatments:

50-150 mg in 2-3 divided doses daily

For:

Route of admnistration

Oral

Defined daily dose

50 - 150 mg

Dosage regimen

From 16.667 To 50 mg 3 time(s) per day every day

Detailed description

Data are very limited in children under 6 years but since the disease is fully penetrant, prophylactic treatment should be considered as early as possible.

The recommended dose is as follows:

  • from 1 to 6 years: 25 mg twice daily.
  • from 6 to 16 years if bodyweight under 57 kg: 25 mg three times daily.
  • from 16 years or if bodyweight above 57 kg: 50 mg three times daily.

Dosage considerations

Zinc must be taken on an empty stomach, at least 1 hour before or 2-3 hours after meals. In case of gastric intolerance, often occurring with the morning dose, this dose may be delayed to mid-morning, between breakfast and lunch. It is also possible to take zinc with a little protein, such as meat.

Active ingredient

Zinc

Zinc blocks the intestinal absorption of copper from the diet and the reabsorption of endogenously secreted copper. Zinc induces the production of metallothionein in the enterocyte, a protein that binds copper thereby preventing its transfer into the blood. The bound copper is then eliminated in the stool following desquamation of the intestinal cells.

Read more about Zinc

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