Active Ingredient: Sulfasalazine
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, between 4 grams sulfasalazine and 8 grams sulfasalazine, divided daily.
1 to 2 g four times a day may be given in conjunction with steroids as part of an intensive management regime. Rapid passage of the suspension may reduce the effect of the drug.
The night time interval between doses should not exceed 8 hours.
For:
Rectal, 1 grams sulfasalazine, 2 times daily.
The dose is adjusted according to the severity of the disease and the patient’s tolerance of the drug.
Two suppositories of 0.5g are to be inserted in the morning and two at bedtime after defecation. After three weeks the dosage is gradually reduced as improvement occurs.
In severe generalised ulcerative colitis of the rectum or recto sigmoid, or in cases who are responding slowly to oral therapy, one or two suppositories of 0.5 g may be given in the morning and at bedtime additional to oral therapy.
For:
Oral, in total between 40 milligrams sulfasalazine and 60 milligrams sulfasalazine, daily.
40-60 mg/kg/day.
The dose is reduced in proportion to body weight.
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