Crohn's disease

Active Ingredient: Sulfasalazine

Indication for Sulfasalazine

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

4-8 g daily in divided doses


Dosage regimens

Oral, between 4 grams sulfasalazine and 8 grams sulfasalazine, divided daily.

Detailed description

1 to 2 g four times a day may be given in conjunction with steroids as part of an intensive management regime. Rapid passage of the suspension may reduce the effect of the drug.

The night time interval between doses should not exceed 8 hours.

1 g twice daily


Dosage regimens

Rectal, 1 grams sulfasalazine, 2 times daily.

Detailed description

The dose is adjusted according to the severity of the disease and the patient’s tolerance of the drug.

Acute attack or relapse – Adults and the Elderly

Two suppositories of 0.5g are to be inserted in the morning and two at bedtime after defecation. After three weeks the dosage is gradually reduced as improvement occurs.

Adjustment to oral therapy – Adults and the Elderly

In severe generalised ulcerative colitis of the rectum or recto sigmoid, or in cases who are responding slowly to oral therapy, one or two suppositories of 0.5 g may be given in the morning and at bedtime additional to oral therapy.

40-60 mg/kg/day


Dosage regimens

Oral, in total between 40 milligrams sulfasalazine and 60 milligrams sulfasalazine, daily.

Detailed description

40-60 mg/kg/day.

The dose is reduced in proportion to body weight.

Active ingredient


Therapeutic benefit of sulfasalazine appears to be due to a local action of the sulfasalazine and its split product 5-aminosalicylic acid on the mucous membrane and deeper colonic structures.

Read more about Sulfasalazine

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