Post-exposure prophylaxis

Active Ingredient: Tetanus immunoglobulin

Indication for Tetanus immunoglobulin

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Preventive action

Immediate prophylaxis after tetanus prone injuries in patients not adequately vaccinated, in patients whose immunisation status is not known with certainty, and in patients with severe deficiency in antibody production or vaccinated patients with high risk wounds.

For this indication, competent medicine agencies globally authorize below treatments:

250-500 IU once

For:

Dosage regimens

Intramuscular, between 250 international units tetanus immunoglobulin and 500 international units tetanus immunoglobulin, daily, one dose.

Detailed description

Prophylaxis of tetanus prone wounds:

  • 250 IU, unless the risk is thought to be extremely high
  • the dose may be increased to 500 IU in:
    • infected wounds, where surgically appropriate treatment cannot be achieved within 24 hours
    • deep or contaminated wounds with tissue damage and reduced oxygen supply, as well as foreign body injury (e.g. bites, stings or shots).

Dosage considerations

If a large volume (>2 ml for children or >5 ml for adults) is required, it is recommended to administer this in divided doses at different sites.

When simultaneous vaccination is necessary, the immunoglobulin and the vaccine should be administered at two different sites.

For prophylaxis, if intramuscular administration is contraindicated (bleeding disorders), the injection can be administered subcutaneously. However, it should be noted that there are no clinical efficacy data to support administration by the subcutaneous route.

Active ingredient

Tetanus immunoglobulin

Human tetanus immunoglobulin contains mainly immunoglobulin G (IgG) with a specifically high content of antibodies against the toxin produced by the bacteria clostridium tetanus.

Read more about Tetanus immunoglobulin

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