Active Ingredient: Oxcarbazepine
Oxcarbazepine is indicated for the treatment of partial seizures with or without secondarily generalised tonicclonic seizures.
Oxcarbazepine is indicated for use as monotherapy or adjunctive therapy in adults and in children of 6 years of age and above.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
600 - 2,400 mg
From 300 To 1,200 mg 2 time(s) per day every day
Oxcarbazepine should be initiated with a dose of 600 mg/day (8-10 mg/kg/day) given in 2 divided doses.
If clinically indicated, the dose may be increased by a maximum of 600 mg/day at approximately weekly intervals from the starting dose to achieve the desired clinical response. Therapeutic effects are seen at doses between 600 mg/day and 2,400 mg/day.
Controlled monotherapy trials in patients not currently being treated with antiepileptic medicinal products showed 1200 mg/day to be an effective dose; however, a dose of 2,400 mg/day has been shown to be effective in more refractory patients converted from other antiepileptic medicinal products to oxcarbazepine monotherapy.
In a controlled hospital setting, dose increases up to 2,400 mg/day have been achieved over 48 hours.
Oxcarbazepine should be initiated with a dose of 600 mg/day (8-10 mg/kg/day) given in 2 divided doses.
If clinically indicated, the dose may be increased by a maximum of 600 mg/day at approximately weekly intervals from the starting dose to achieve the desired clinical response. Therapeutic responses are seen at doses between 600 mg/day and 2,400 mg/day.
Daily doses from 600 to 2,400 mg/day have been shown to be effective in a controlled adjunctive therapy trial, although most patients were not able to tolerate the 2,400 mg/day dose without reduction of concomitant antiepileptic medicinal products, mainly because of CNS-related adverse events. Daily doses above 2,400 mg/day have not been studied systematically in clinical trials.
Oxcarbazepine can be taken with or without food.
Oral
8 - 32 mg per kg of body weight
From 4 To 16 mg per kg of body weight 2 time(s) per day every day
Oxcarbazepine should be initiated with a dose of 600 mg/day (8-10 mg/kg/day) given in 2 divided doses.
If clinically indicated, the dose may be increased by a maximum of 600 mg/day at approximately weekly intervals from the starting dose to achieve the desired clinical response. Therapeutic effects are seen at doses between 600 mg/day and 2,400 mg/day.
Controlled monotherapy trials in patients not currently being treated with antiepileptic medicinal products showed 1200 mg/day to be an effective dose; however, a dose of 2,400 mg/day has been shown to be effective in more refractory patients converted from other antiepileptic medicinal products to oxcarbazepine monotherapy.
In a controlled hospital setting, dose increases up to 2,400 mg/day have been achieved over 48 hours.
Oxcarbazepine should be initiated with a dose of 600 mg/day (8-10 mg/kg/day) given in 2 divided doses.
If clinically indicated, the dose may be increased by a maximum of 600 mg/day at approximately weekly intervals from the starting dose to achieve the desired clinical response. Therapeutic responses are seen at doses between 600 mg/day and 2,400 mg/day.
Daily doses from 600 to 2,400 mg/day have been shown to be effective in a controlled adjunctive therapy trial, although most patients were not able to tolerate the 2,400 mg/day dose without reduction of concomitant antiepileptic medicinal products, mainly because of CNS-related adverse events. Daily doses above 2,400 mg/day have not been studied systematically in clinical trials.
Oxcarbazepine can be taken with or without food.
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