Sedation during minor medical procedures

Active Ingredient: Midazolam

Indication for Midazolam

Population group: only adults (18 - 65 years old)

As intravenous sedative cover before and during minor medical, dental and surgical procedures such as gastroscopy, endoscopy, cystoscopy, bronchoscopy and cardiac catheterisation.

For this indication, competent medicine agencies globally authorize below treatments:

2.0-7.5 mg

Route of admnistration


Defined daily dose

2 - 7.5 mg

Dosage regimen

From 2 To 7.5 mg once every day

Detailed description

An assessment should be made of the degree of sedation necessary for the planned procedure.

The dose should be titrated against the response of the patient. The desired titration end point will depend upon the procedure. Full sedation will be evident by drowsiness, slurred speech but response to commands will be maintained.

As a guide, it is recommended that 0.4ml of midazolam 5mg/ml solution (equivalent to 2mg midazolam) be administered intravenously over 30 seconds. If after 2 minutes, sedation is not adequate, incremental doses of 0.1ml to 0.2ml of midazolam 5mg/ml solution (0.5 to 1mg midazolam) should be given.

Usual dose range 2.5mg-7.5mg total dose (equivalent to around 0.07mg/kg body weight).

Dosages greater than 5.0mg are not usually necessary.

Active ingredient


Midazolam is a derivative of the imidazobenzodiazepine group. The free base is a lipophilic substance with low solubility in water. The basic nitrogen in position 2 of the imidazobenzodiazepine ring system enables the active ingredient of midazolam to form water-soluble salts with acids.

Read more about Midazolam

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