Primary hypercholesterolemia, mixed dyslipidaemia

Active Ingredient: Simvastatin

Indication for Simvastatin

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Treatment of primary hypercholesterolaemia or mixed dyslipidaemia, as an adjunct to diet, when response to diet and other non-pharmacological treatments (e.g. exercise, weight reduction) is inadequate.

For this indication, competent medicine agencies globally authorize below treatments:

10-80 mg once daily


Dosage regimens

Oral, between 10 milligrams simvastatin and 80 milligrams simvastatin, once daily at evening.

Detailed description

The dosage range is 5-80 mg/day given orally as a single dose in the evening. Adjustments of dosage, if required, should be made at intervals of not less than 4 weeks, to a maximum of 80 mg/day given as a single dose in the evening. The 80 mg dose is only recommended in patients with severe hypercholesterolaemia and high risk for cardiovascular complications who have not achieved their treatment goals on lower doses and when the benefits are expected to outweigh the potential risks.


The patient should be placed on a standard cholesterol-lowering diet, and should continue with this diet during treatment with Simvastatin. The usual starting dose is 10-20 mg/day given as a single dose in the evening. Patients who require a large reduction in LDL-C (more than 45%) may be started at 20-40-mg/day given as a single dose in the evening. Adjustments of dosage, if required, should be made as specified above.

Dosage considerations

It can be administered as a single dose in the evening.

Active ingredient


Simvastatin has a potent activity in inhibiting HMG-CoA reductase (3-hydroxy–3-ethylglutaryl-CoA-reductase). Simvastatin has been shown to reduce both normal and elevated LDL-C concentrations.

Read more about Simvastatin

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