Established atherosclerotic cardiovascular disease

Active Ingredient: Evolocumab

Indication for Evolocumab

Population group: only adults (18 years old or older)

Evolocumab is indicated in adults with established atherosclerotic cardiovascular disease (myocardial infarction, stroke or peripheral arterial disease) to reduce cardiovascular risk by lowering LDL-C levels, as an adjunct to correction of other risk factors:

  • in combination with the maximum tolerated dose of a statin with or without other lipid-lowering therapies or,
  • alone or in combination with other lipid-lowering therapies in patients who are statin-intolerant, or for whom a statin is contraindicated.

For this indication, competent medicine agencies globally authorize below treatments:

140 mg once every two weeks

Route of admnistration

Subcutaneous

Defined daily dose

140 - 140 mg

Dosage regimen

From 140 To 140 mg once every 14 day(s)

Detailed description

The recommended dose of evolocumab is either 140 mg every two weeks.

Dosage considerations

Evolocumab is for subcutaneous injection into the abdomen, thigh or upper arm region. Injection sites should be rotated and injections should not be given into areas where the skin is tender, bruised, red, or hard.

420 mg once every month

Route of admnistration

Subcutaneous

Defined daily dose

420 - 420 mg

Dosage regimen

From 420 To 420 mg once every 28 day(s)

Detailed description

The recommended dose of evolocumab is 420 mg once monthly.

Dosage considerations

Evolocumab is for subcutaneous injection into the abdomen, thigh or upper arm region. Injection sites should be rotated and injections should not be given into areas where the skin is tender, bruised, red, or hard.

Active ingredient

Evolocumab

Evolocumab binds selectively to PCSK9 and prevents circulating PCSK9 from binding to the low density lipoprotein receptor (LDLR) on the liver cell surface, thus preventing PCSK9-mediated LDLR degradation. Increasing liver LDLR levels results in associated reductions in serum LDL-cholesterol (LDL-C).

Read more about Evolocumab

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