Soft-tissue sarcoma (STS)

Active Ingredient: Pazopanib

Indication for Pazopanib

Population group: only adults (18 years old or older)

Pazopanib is indicated for the treatment of adult patients with selective subtypes of advanced soft-tissue sarcoma (STS) who have received prior chemotherapy for metastatic disease or who have progressed within 12 months after (neo) adjuvant therapy.

For this indication, competent medicine agencies globally authorize below treatments:

800 mg once daily

Route of admnistration

Oral

Defined daily dose

800 - 800 mg

Dosage regimen

From 800 To 800 mg once every day

Detailed description

The recommended dose of pazopanib is 800 mg once daily.

Dose modifications: Dose modification (decrease or increase) should be in 200 mg decrements or increments in a stepwise fashion based on individual tolerability in order to manage adverse reactions. The dose of pazopanib should not exceed 800 mg.

Dosage considerations

It should be taken without food, at least one hour before or two hours after a meal.

Active ingredient

Pazopanib

Pazopanib is an orally administered, potent multi-target tyrosine kinase inhibitor (TKI) of vascular endothelial growth factor receptors (VEGFR) -1, -2, and -3, platelet-derived growth factor (PDGFR) -α and -β, and stem cell factor receptor (c-KIT), with IC50 values of 10, 30, 47, 71, 84 and 74 nM, respectively.

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