Postoperative paralytic ileus

Active Ingredient: Trimebutine

Indication for Trimebutine

Population group: only adults (18 years old or older)

Trimebutine maleate is indicated in postoperative paralytic ileus in order to accelerate the resumption of the intestinal transit following abdominal surgery.

For this indication, competent medicine agencies globally authorize below treatments:

200-600 mg in 3 divided doses daily

Route of admnistration

Oral

Defined daily dose

200 - 600 mg

Dosage regimen

From 66.667 To 200 mg 3 time(s) per day every day

Detailed description

The adult recommended dose is up to 600 mg daily in divided doses.

Dosage considerations

Should be given before meals.

Active ingredient

Trimebutine

Trimebutine maleate is a noncompetitive spasmolytic agent. It possesses moderate opiate receptor affinity and has a marked antiserotonin activity especially on ‘M’ receptors. It induces regulation of spontaneous activity and increases synchronization between electrophysiological spikes and contractions in isolated guinea pig taenia coli and ileum. However, it does not alter normal motility, but regulates abnormal intestinal activity.

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