Idiopathic edema

Active Ingredient: Triamterene

Indication for Triamterene

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

100 mg twice daily and thereafter 100-300 mg total daily dose

For:

Dosage regimens

Oral, 100 milligrams triamterene, 2 times daily. Afterwards, oral, between 100 milligrams triamterene and 300 milligrams triamterene, divided daily, 1 to 2 doses in total. The maximum allowed total dose is 300 milligrams triamterene daily.

Detailed description

Dosage should be titrated to the needs of the individual patient. When used alone, the usual starting dose is 100 mg twice daily after meals.

When combined with another diuretic or antihypertensive agent, the total daily dosage of each agent should usually be lowered initially and then adjusted to the patient’s needs.

The total daily dosage should not exceed 300 mg.

When triamterene is added to other diuretic therapy or when patients are switched to triamterene from other diuretics, all potassium supplementation should be discontinued.

Dosage considerations

To help avoid stomach upset, it is recommended that the drug be taken after meals.

If a single daily dose is prescribed, it may be preferable to take it in the morning to minimize the effect of increased frequency of urination on nighttime sleep.

If a dose is missed, the patient should not take more than the prescribed dose at the next dosing interval.

Active ingredient

Triamterene

Triamterene is a potassium-sparing agent. Triamterene inhibits the reabsorption of sodium ions in exchange for potassium and hydrogen ions at that segment of the distal tubule under the control of adrenal mineralocorticoids (especially aldosterone). The fraction of filtered sodium reaching this distal tubular exchange site is relatively small, and the amount which is exchanged depends on the level of mineralocorticoid activity. Thus, the degree of natriuresis and diuresis produced by inhibition of the exchange mechanism is necessarily limited.

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