Active Ingredient: Vismodegib
Vismodegib is indicated for the treatment of adult patients with:
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 150 milligrams vismodegib, once daily.
The recommended dose is 150 mg once daily.
If a dose is missed, patients should be instructed not to take the missed dose but to resume with the next scheduled dose.
In clinical trials, treatment with vismodegib was continued until disease progression or until unacceptable toxicity. Treatment interruptions of up to 4 weeks were allowed based on individual tolerability.
Benefit of continued treatment should be regularly assessed, with the optimal duration of therapy varying for each individual patient.
No dose adjustment is required in patients ≥65 years of age. Of a total number of 138 patients in 4 clinical studies of vismodegib in advanced basal cell carcinoma, approximately 40% of patients were ≥65 years old and no overall differences in safety and efficacy were observed between these patients and younger patients.
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