Severe Raynaud's Phenomenon

Active Ingredient: Iloprost

Indication for Iloprost

Population group: only adults (18 - 65 years old)

For this indication, competent medicine agencies globally authorize below treatments:

1.5-2.0 ng/kg/min

Route of admnistration

Intravenous

Defined daily dose

1.5 - 2 ng per kg of body weight

Dosage regimen

From 1.5 To 2 ng per kg of body weight once every day

Detailed description

The recommended dosage varies between 1.5 to 2 ng/kg/min depending on the patient’s tolerance. Treatment should be started at 0.5 ng/kg/min (i.e. 10 ml/h) and increased gradually every 30 minutes, according to the scheme proposed above, to reach the maximum tolerated dose by the patient. The duration of the infusion will be 6h/per day for 5 consecutive days, using the maximum tolerated dose determined during the first days of treatment.

Repeat cycles should preferably take place at intervals of 6 to 12 weeks (and never less than 4 weeks).

Active ingredient

Iloprost

Iloprost is a synthetic prostacyclin analogue. After inhalation of iloprost direct vasodilatation of the pulmonary arterial bed occur with consecutive significant improvement of pulmonary artery pressure, pulmonary vascular resistance and cardiac output as well as mixed venous oxygen saturation.

Read more about Iloprost

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