Helicobacter pylori associated with duodenal ulcer

Indication for Tinidazole

Population group: Suitable for both men and women, only adolescents (12 years - 18 years old) , adults (18 years old or older)

Eradication of Helicobacter pylori associated with duodenal ulcers, in the presence of antibiotic and acid suppressant therapy.

For this indication, competent medicine agencies globally authorize below treatments:

1,000 mg in 2 divided doses daily

Route of admnistration


Defined daily dose

1,000 - 1,000 mg

Dosage regimen

From 500 To 500 mg 2 time(s) per day every day

Detailed description

The usual dose of tinidazole is 500mg twice daily coadministered with omeprazole 20mg twice daily and clarithromycin 250mg twice daily for 7 days.

Clinical studies using this 7 day regimen have shown similar H. pylori eradication rates when omeprazole 20mg once daily was used.

Dosage considerations

It should be taken during or after a meal.

Active ingredient

Tinidazole is active against both protozoa and obligate anaerobic bacteria. The activity against protozoa involves Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia. The mode of action of tinidazole against anaerobic bacteria and protozoa involves penetration of the drug into the cell of the micro-organism and subsequent damage of DNA strands or inhibition of their synthesis.

Read more about Tinidazole

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