Idiopathic pulmonary fibrosis (IPF)

Active Ingredient: Nintedanib

Indication for Nintedanib

Population group: only adults (18 years old or older)

Nintedanib is indicated in adults for the treatment of idiopathic pulmonary fibrosis (IPF).

For this indication, competent medicine agencies globally authorize below treatments:

300 mg in 2 divided doses daily

Route of admnistration

Oral

Defined daily dose

300 - 300 mg

Dosage regimen

From 150 To 150 mg 2 time(s) per day every day

Detailed description

The recommended dose is 150 mg nintedanib twice daily administered approximately 12 hours apart.

The 100 mg twice daily dose is only recommended to be used in patients who do not tolerate the 150 mg twice daily dose.

If a dose is missed, administration should resume at the next scheduled time at the recommended dose. If a dose is missed the patient should not take an additional dose. The recommended maximum daily dose of 300 mg should not be exceeded.

Dosage considerations

It must be taken orally, preferably with food.

Active ingredient

Nintedanib

Nintedanib is a triple angiokinase inhibitor blocking vascular endothelial growth factor receptors (VEGFR 1-3), platelet-derived growth factor receptors (PDGFR α and β) and fibroblast growth factor receptors (FGFR 1-3) kinase activity. Nintedanib binds competitively to the adenosine triphosphate (ATP) binding pocket of these receptors and blocks the intracellular signalling which is crucial for the proliferation and survival of endothelial as well as perivascular cells (pericytes and vascular smooth muscle cells).

Read more about Nintedanib

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