Severe hypertriglyceridaemia, mixed hyperlipidaemia, primary hypercholesterolaemia

Active Ingredient: Gemfibrozil

Indication for Gemfibrozil

Population group: only adults (18 years old or older)

Gemfibrozil is indicated as an adjunct to diet and other non-pharmacological treatment (e.g. exercise, weight reduction) for the following:

  • Treatment of severe hypertriglyceridaemia with or without low HDL cholesterol.
  • Mixed hyperlipidaemia when a statin is contraindicated or not tolerated.
  • Primary hypercholesterolaemia when a statin is contraindicated or not tolerated.

For this indication, competent medicine agencies globally authorize below treatments:

900-1,200 mg daily


Dosage regimens

Regimen A: Oral, 900 milligrams gemfibrozil, once daily -30 minutes before dinner.

Regimen B: Oral, 600 milligrams gemfibrozil, 2 times daily -30 minutes before meals.

Detailed description

The dose range is 900 mg to 1,200 mg daily.

The only dose with documented effect on morbidity is 1,200 mg daily.

Dosage considerations

The 1,200 mg dose is taken as 600 mg twice daily, half an hour before breakfast and half an hour before the evening meal.

The 900 mg dose is taken as a single dose half an hour before the evening meal.

Active ingredient


Gemfibrozil is a lipid regulating agent which regulates lipid fractions. Gemfibrozil stimulates the peripheral lipolysis of triglyceride rich lipoproteins such as VLDL and cholymicrons by stimulation of LPL. Gemfibrozil also inhibits synthesis of VLDL in the liver.

Read more about Gemfibrozil

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