Hypertension

Active Ingredient: Propranolol

Indication for Propranolol

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

160-320 mg in 2 divided doses daily

Route of admnistration

Oral

Defined daily dose

160 - 320 mg

Dosage regimen

From 80 To 160 mg 2 time(s) per day every day

Loading dose

160 mg

Detailed description

Initially 80 mg twice daily, which may be increased at weekly intervals according to response. The usual dose range is 160-320 mg/daily. With concurrent diuretic or other antihypertensive drugs a further reduction of blood pressure is obtained.

Active ingredient

Propranolol

Propranolol is a competitive antagonist at both beta, and beta2-adrenoceptor, but has membrane stabilising activity at concentrations exceeding 1-3mg/litre, though such concentrations are rarely achieved during oral therapy. Competitive beta-blockade has been demonstrated in man by a parallel shift to the right in the dose-heart rate response curve to beta-agonists such as isoprenaline.

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