Post-exposure prophylaxis of COVID-19

Active Ingredient: Ensitrelvir

Indication for Ensitrelvir

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Preventive action

Ensitrelvir is indicated for the post-exposure prophylaxis of COVID-19 in adults and adolescents aged 12 years and older.

Ensitrelvir should be used in accordance with official recommendations.

For this indication, competent medicine agencies globally authorize below treatments:

375 mg once daily on Day 1 and 125 mg once daily from Days 2 to 5 for a total of 5 days

For:

Dosage regimens

Oral, 375 milligrams ensitrelvir, one dose, over the duration of 1 day. Afterwards, oral, 125 milligrams ensitrelvir, once daily, over the duration of 4 days.

Detailed description

Adults and adolescents aged 12 years and older

The recommended dose for patients 12 years and older is 375 mg of ensitrelvir orally once daily on Day 1 and 125 mg once daily from Days 2 to 5 for a total of 5 days.

It is recommended that administration should be started as soon as possible and within 72 hours following close contact with an individual who has SARS-CoV-2 infection.

Missed dose

In case of missed dose, the patient should take it as soon as possible and resume the normal dosing schedule. If it is almost time for the next dose, the patient should not take the missed dose and instead take the next dose at the regularly scheduled time. The patient should not double the dose to make up for a forgotten one.

Active ingredient

Ensitrelvir

Ensitrelvir selectively inhibits SARS-CoV-2 3C-like (3CL) protease, an essential enzyme for the processing of the polyprotein encoded by the SARS-CoV-2 gene, which thereby inhibits SARS-CoV-2 replication. The 50% inhibitory concentration (IC50) of ensitrelvir for SARS-CoV-2 3CL protease activity was 0.0132 μmol/L.

Read more about Ensitrelvir

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