Insomnia

Active Ingredient: Zolpidem

Indication for Zolpidem

Population group: only adults (18 - 65 years old)

Zolpidem is indicated for the short-term treatment of insomnia in adults in situations where the insomnia is debilitating or is causing severe distress for the patient.

For this indication, competent medicine agencies globally authorize below treatments:

10 mg once daily

Route of admnistration

Oral

Defined daily dose

10 - 10 mg

Dosage regimen

From 10 To 10 mg once every day

Loading dose

10 mg

Maintenance dose

10 mg

Detailed description

The treatment should be taken in a single intake and not be re-administered during the same night. The recommended daily dose for adults is 10 mg to be taken immediately at bedtime. The lowest effective daily dose of zolpidem tartrate should be used and must not exceed 10 mg.

The duration of treatment should usually vary from a few days to two weeks with a maximum of four weeks including tapering off where clinically appropriate. Treatment should be as short as possible. It should not exceed four weeks including the period of tapering off. In certain cases extension beyond the maximum treatment period may be necessary; if so, extension beyond the maximum treatment period should not take place without re-evaluation of the patient’s status, since the risk of abuse and dependence increases with the duration of treatment.

Dosage considerations

It should be taken immediately at bedtime.

Active ingredient

Zolpidem

Zolpidem is an imidazopyridine which preferentially binds the omega-1 receptor subtype (also known as the benzodiazepine-1 subtype) which corresponds to GABA-A receptors containing the alpha-1 sub-unit, whereas benzodiazepines non-selectively bind both omega-1 and omega-2 subtypes. The modulation of the chloride anion channel via this receptor leads to the specific sedative effects demonstrated by zolpidem. These effects are reversed by the benzodiazepine antagonist flumazenil.

Read more about Zolpidem

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