Ulcerative colitis

Active Ingredient: Sulfasalazine

Indication for Sulfasalazine

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Curative procedure

Induction and maintenance of remission of ulcerative colitis.

For this indication, competent medicine agencies globally authorize below treatments:

20-60 mg/kg/day


Dosage regimens

Oral, in total between 20 milligrams sulfasalazine and 60 milligrams sulfasalazine, daily.

Detailed description

Acute attack or relapse: 40-60 mg/kg/day.

Maintenance dosage: 20-30 mg/kg/day.

The dose is reduced in proportion to body weight.

4-8 g in divided doses daily


Dosage regimens

Oral, between 4 grams sulfasalazine and 8 grams sulfasalazine, divided daily.

Detailed description

Severe attacks: 1 to 2 g four times a day may be given in conjunction with steroids as part of an intensive management regime. Rapid passage of the suspension may reduce the effect of the drug.

The night time interval between doses should not exceed 8 hours.

Moderate attacks: 1 g four times a day may be taken with or without steroids.

Maintenance therapy: With induction of remission, reduce the dose gradually to 2 g per day. This dosage should be continued indefinitely, since discontinuance even several years after an acute attack is associated with a four-fold increase in relapse.

Active ingredient


Therapeutic benefit of sulfasalazine appears to be due to a local action of the sulfasalazine and its split product 5-aminosalicylic acid on the mucous membrane and deeper colonic structures.

Read more about Sulfasalazine

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