Active Ingredient: Sulfasalazine
Induction and maintenance of remission of ulcerative colitis.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, in total between 20 milligrams sulfasalazine and 60 milligrams sulfasalazine, daily.
Acute attack or relapse: 40-60 mg/kg/day.
Maintenance dosage: 20-30 mg/kg/day.
The dose is reduced in proportion to body weight.
For:
Oral, between 4 grams sulfasalazine and 8 grams sulfasalazine, divided daily.
Severe attacks: 1 to 2 g four times a day may be given in conjunction with steroids as part of an intensive management regime. Rapid passage of the suspension may reduce the effect of the drug.
The night time interval between doses should not exceed 8 hours.
Moderate attacks: 1 g four times a day may be taken with or without steroids.
Maintenance therapy: With induction of remission, reduce the dose gradually to 2 g per day. This dosage should be continued indefinitely, since discontinuance even several years after an acute attack is associated with a four-fold increase in relapse.
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