Induction and maintenance of remission of ulcerative colitis.
For this indication, competent medicine agencies globally authorize below treatments:
For: Children Adolescents
Oral, in total between 20 and 60 milligrams, daily.
Acute attack or relapse: 40-60 mg/kg/day.
Maintenance dosage: 20-30 mg/kg/day.
The dose is reduced in proportion to body weight.
For: Adults (18-64) Elders (65+)
Oral, between 4 and 8 grams, divided daily.
Severe attacks: 1 to 2 g four times a day may be given in conjunction with steroids as part of an intensive management regime. Rapid passage of the suspension may reduce the effect of the drug.
The night time interval between doses should not exceed 8 hours.
Moderate attacks: 1 g four times a day may be taken with or without steroids.
Maintenance therapy: With induction of remission, reduce the dose gradually to 2 g per day. This dosage should be continued indefinitely, since discontinuance even several years after an acute attack is associated with a four-fold increase in relapse.
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