Diabetes mellitus type 2

Active Ingredient: Empagliflozin

Indication for Empagliflozin

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Empagliflozin is indicated for the treatment of adults with insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise:

  • As monotherapy when metformin is considered inappropriate due to intolerance.
  • In addition to other medicinal products for the treatment of diabetes.

For this indication, competent medicine agencies globally authorize below treatments:

10 mg once daily

For:

Dosage regimens

Oral, 10 milligrams empagliflozin, once daily. The maximum allowed total dose is 25 milligrams empagliflozin daily.

Detailed description

The recommended starting dose is 10 mg empagliflozin once daily for monotherapy and add-on combination therapy with other medicinal products for the treatment of diabetes.

In patients tolerating empagliflozin 10 mg once daily who have an eGFR ≥60 ml/min/1.73 m² and need tighter glycaemic control, the dose can be increased to 25 mg once daily. The maximum daily dose is 25 mg.

When empagliflozin is used in combination with a sulphonylurea or with insulin, a lower dose of the sulphonylurea or insulin may be considered to reduce the risk of hypoglycaemia.

If a dose is missed, it should be taken as soon as the patient remembers; however, a double dose should not be taken on the same day.

Elderly

No dose adjustment is recommended based on age. In patients 75 years and older, an increased risk for volume depletion should be taken into account.

Dosage considerations

Can be taken with or without food.

Active ingredient

Empagliflozin

Empagliflozin is a reversible, highly potent (IC50 of 1.3 nmol) and selective competitive inhibitor of sodium-glucose co-transporter 2 (SGLT2). Empagliflozin improves glycaemic control in patients with type 2 diabetes by reducing renal glucose reabsorption.

Read more about Empagliflozin

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