Active Ingredient: Maribavir
Maribavir is indicated for the treatment of cytomegalovirus (CMV) infection and/or disease that are refractory (with or without resistance) to one or more prior therapies, including ganciclovir, valganciclovir, cidofovir or foscarnet in adult patients who have undergone a haematopoietic stem cell transplant (HSCT) or solid organ transplant (SOT).
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: Oral, 400 milligrams maribavir, 2 times daily, over the duration of 8 weeks.
Regimen B: In case that there is substance induction of cytochrome p450 enzyme, oral, 1,200 milligrams maribavir, 2 times daily, over the duration of 8 weeks.
The recommended dose of maribavir is 400 mg (two 200 mg tablets) twice daily resulting in a daily dose of 800 mg for 8 weeks. Treatment duration may need to be individualised based on the clinical characteristics of each patient.
Co-administration of maribavir with the strong cytochrome P450 3A (CYP3A) inducers rifampicin, rifabutin or St. John’s wort is not recommended due to potential for a decrease in efficacy of maribavir.
If co-administration of maribavir with other strong or moderate CYP3A inducers (e,g., carbamazepine, efavirenz, phenobarbital and phenytoin) cannot be avoided, the maribavir dose should be increased to 1 200 mg twice daily.
Patients should be instructed that if they miss a dose of maribavir, and the next dose is due within the next 3 hours, they should skip the missed dose and continue with the regular schedule. Patients should not double their next dose or take more than the prescribed dose.
It can be taken with or without food.
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