Pain

Active Ingredient: Nitrous oxide (N2O)

Indication for Nitrous oxide (N2O)

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Nitrous oxide (N2O) is used exclusively for the relief of pain.

Common examples of the use of nitrous oxide are:

  • acute trauma
  • short-term relief in dental work
  • short-term relief for procedures inevitably involving pain, such as wound and burn dressing, wound debridement and suturing
  • normal labour
  • acute surgical or medical conditions in which the pain is relieved, only to return on cessation of the analgesia so allowing an unfettered assessment to be made.

For this indication, competent medicine agencies globally authorize below treatments:

1 lt in 24 hours

Route of admnistration

Respiratory (Inhalation)

Defined daily dose

1 - 1 L

Dosage regimen

From 1 To 1 L once every day for 1 day(s)

Detailed description

Nitrous oxide is administered through a facemask or mouthpiece. The face mask or mouthpiece is connected to an nitrous oxide supply through a demand valve system which allows the nitrous oxide to be self-regulated by the patient. The demand valve is operated by the act of inhalation of the patient and closes down when the patient ceases to inhale.

In nearly all cases, nitrous oxide is self-administered, but it may be administered by attendant medical personnel. Since pain is usually relieved by a concentration of 25% nitrous oxide, continued inhalation does not occur. However, should inhalation continue, light anaesthesia occurs and the mask or mouthpiece drops away as the patient relaxes, or is removed if administration has been by attendant personnel.

There are no contraindications to the use of nitrous oxide in any age group. Nitrous oxide should not be used for more than a total of 24 hours, or more frequently than every 4 days, without close clinical supervision and haematological monitoring.

Active ingredient

Nitrous oxide (N2O)

Nitrous oxide is a potent analgesic and a weak anaesthetic. Induction with nitrous oxide is relatively rapid, but a concentration of about 70% is needed to produce unconsciousness.

Read more about Nitrous oxide (N2O)

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