Acne vulgaris

Indication for Azelaic acid

Population group: Suitable for both men and women, only adolescents (12 years - 18 years old) , adults (18 - 65 years old)

Azelaic acid is indicated for the topical treatment of acne vulgaris.

For this indication, competent medicine agencies globally authorize below treatments:

2 spreads in 2 divided doses daily

Route of admnistration

Cutaneous

Defined daily dose

2 - 2 {spreads}

Dosage regimen

From 1 To 1 {spreads} 2 time(s) per day every day

Detailed description

Azelaic acid should be applied to the affected areas of skin twice daily (mornings and evenings), and rubbed in gently. As a guide 2.5 cm (approx. 0.5 g) of cream is sufficient for the entire facial area. If other areas of acne, in addition to the face require treatment, for example the chest and back, the amount of cream should be adjusted accordingly.

Patients with sensitive skin should be advised to use azelaic acid only once a day (in the evening) for the first week of treatment and then proceed to twice daily applications.

Before azelaic acid is applied, the skin should be thoroughly cleaned with plain water and dried. A mild skin-cleansing agent may be used.

The duration of use of azelaic acid can vary from patient to patient and also depends on the severity of the acne. In general, a distinct improvement becomes apparent after about 4 weeks. To obtain the best results, azelaic acid should be used continuously over a period of several months.

It is important to continue to use azelaic acid regularly over the entire period of treatment. However, in the event of intolerable skin irritation, the amount of cream per application should be reduced or the frequency of use of azelaic acid should be reduced to once a day until the irritation ceases. If required, treatment might have to be temporarily interrupted for a few days.

Active ingredient

Azelaic Acid is a naturally occurring dicarboxylic acid. Azelaic acid possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity. Azelaic acid is bactericidal against Proprionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular proteins.

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