Lenograstim is indicated in adults, adolescents and children aged older than 2 years for the reduction of the duration of neutropenia in patients (with non myeloid malignancy) undergoing myeloablative therapy followed by bone marrow transplantation (BMT) and considered to be at increased risk of prolonged severe neutropenia.
For this indication, competent medicine agencies globally authorize below treatments:
Subcutaneous
150 - 150 ug per m² of body surface area (BSA)
From 150 To 150 ug per m² of body surface area (BSA) once every day
Lenograstim should be administered daily at the recommended dose of 19.2 MIU (150 µg) per m² per day as a 30-minute intravenous infusion diluted in isotonic saline solution or as a subcutaneous injection. The first dose should not be administered within 24 hours of the bone marrow infusion. Dosing should continue until the expected nadir has passed and the neutrophil count returns to a stable level compatible with treatment discontinuation, with, if necessary, a maximum of 28 consecutive days of treatment.
It is anticipated that by day 14 following bone marrow transplantation, 50% of patients will achieve neutrophil recovery.
Subcutaneous
19,200,000 - 19,200,000 [iU] per m² of body surface area (BSA)
From 19,200,000 To 19,200,000 [iU] per m² of body surface area (BSA) once every day
Lenograstim should be administered daily at the recommended dose of 19.2 MIU (150 µg) per m² per day as a 30-minute intravenous infusion diluted in isotonic saline solution or as a subcutaneous injection. The first dose should not be administered within 24 hours of the bone marrow infusion. Dosing should continue until the expected nadir has passed and the neutrophil count returns to a stable level compatible with treatment discontinuation, with, if necessary, a maximum of 28 consecutive days of treatment.
It is anticipated that by day 14 following bone marrow transplantation, 50% of patients will achieve neutrophil recovery.
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