Maintenance of anaesthesia

Active Ingredient: Propofol

Indication for Propofol

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

4-12 mg/kg


Dosage regimens

Intravenous, between 4 milligrams propofol per kilogram of body weight and 12 milligrams propofol per kilogram of body weight, over the duration of 1 hour.

Detailed description

Anaesthesia can be maintained by administering propofol 1% either by continuous infusion or repeat bolus injections.

For maintenance of anaesthesia generally doses of 4 to 12 mg propofol/kg bodyweight/h should be given. A reduced maintenance dose of approximately 4 mg propofol/kg bodyweight/h may be sufficient during less stressful surgical procedures such as minimal invasive surgery.

In elderly patients, patients in unstable general conditions, patients with impaired cardiac function or hypovolaemic patients and patients of ASA grades III and IV the dosage of propofol 1% may be reduced further depending on the severity of the patient’s condition and on the performed anaesthetic technique.

For maintenance of anaesthesia with propofol 1% using repeat bolus injections dose increments of 25 to 50 mg propofol (= 2.5-5 ml propofol 1%) should be given according to clinical requirements.

Rapid bolus administration (single or repeated) with propofol 1% should not be used in the elderly as this may lead to cardiopulmonary depression.

9-15 mg/kg/h


Route of admnistration

Defined daily dose

Dosage regimen

$d time(s) per day every $document.frequencyDenominator day(s)

Detailed description

Anaesthesia can be maintained by administering propofol 1% by infusion or repeated bolus injection to maintain the depth of anaesthesia required. The required rate of administration varies considerably between patients but rates in the region of 9-15 mg/kg/h usually achieve satisfactory anaesthesia. In younger children, especially between the age of 1 month and 3 years, dose requirements may be higher.

For ASA III and IV patients lower doses are recommended.

Active ingredient


Propofol (2, 6-diisopropylphenol) is a short-acting general anaesthetic agent with a rapid onset of action of approximately 30 seconds.

Read more about Propofol

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