Active Ingredient: Propofol
Propofol is a short-acting intravenous general anaesthetic for sedation for maintenance of general anaesthesia in adults and children over one month of age.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, between 4 milligrams propofol per kilogram of body weight and 12 milligrams propofol per kilogram of body weight, over the duration of 1 hour.
Anaesthesia can be maintained by administering propofol either by continuous infusion or by repeat bolus injections to maintain the depth of anaesthesia required.
Continuous Infusion: Propofol 1% may be used. The required rate of administration varies considerably between patients but rates in the region of 4 to 12 mg/kg/h usually maintain satisfactory anaesthesia.
Repeat Bolus Injection: If a technique involving repeat bolus injection is used, increments of 25 mg to 50 mg may be used according to clinical need.
Where propofol is used for maintenance of anaesthesia or sedation the rate of infusion or 'target concentration' should also be reduced. Patients of ASA grades 3 and 4 will require further reductions in dose and dose rate. Rapid bolus administration (single or repeated) should not be used in older people as this may lead to cardiorespiratory depression.
For:
In the case that patient age in months is ≥ 1 :
Intravenous, between 9 milligrams propofol per kilogram of body weight and 15 milligrams propofol per kilogram of body weight, over the duration of 1 hour.
Anaesthesia can be maintained by administering propofol 1% by infusion or repeated bolus injection to maintain the depth of anaesthesia required. The required rate of administration varies considerably between patients but rates in the region of 9-15 mg/kg/h usually achieve satisfactory anaesthesia. In younger children, especially between the age of 1 month and 3 years, dose requirements may be higher.
For ASA III and IV patients lower doses are recommended.
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