Invasive candidiasis

Active Ingredient: Micafungin

Indication for Micafungin

Population group: only newborns (0 - 40 days old) , infants (40 days - 1 year old)

Treatment of invasive candidiasis.

For this indication, competent medicine agencies globally authorize below treatments:

4-10 mg/kg once daily

Route of admnistration

Intravenous

Defined daily dose

4 - 10 mg per kg of body weight

Dosage regimen

From 4 To 10 mg per kg of body weight once every day

Detailed description

Use in children (including neonates) <4 months of age:

Indication 
Treatment of invasive candidiasis4-10 mg/kg/day*

* Micafungin dosed at 4 mg/kg in children less than 4 months approximates drug exposures achieved in adults receiving 100 mg/day for the treatment of invasive candidiasis. If central nervous system (CNS) infection is suspected, a higher dosage (e.g. 10 mg/kg) should be used due to the dose-dependent penetration of micafungin into the CNS.

Treatment duration

Invasive candidiasis: The treatment duration of Candida infection should be a minimum of 14 days. The antifungal treatment should continue for at least one week after two sequential negative blood cultures have been obtained and after resolution of clinical signs and symptoms of infection.

Dosage considerations

After reconstitution and dilution, the solution should be administered by intravenous infusion over approximately 1 hour.

Active ingredient

Micafungin

Micafungin non-competitively inhibits the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall. 1,3-β-D-glucan is not present in mammalian cells. Micafungin exhibits fungicidal activity against most Candida species and prominently inhibits actively growing hyphae of Aspergillus species.

Read more about Micafungin

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