Neurocysticercosis (NCC)

Active Ingredient: Albendazole

Indication for Albendazole

Population group: only adults (18 - 65 years old)

ฮ‘lbendazole is effective in the treatment of neurocysticercosis (NCC) in courses as short as 7 days.

For this indication, competent medicine agencies globally authorize below treatments:

800mg daily, taken in two divided does (400 mg twice daily)

Route of admnistration

Oral

Defined daily dose

800 - 800 mg

Dosage regimen

From 400 To 400 mg 2 time(s) per day every day for 7 day(s)

Detailed description

The dose is 800mg daily, taken in two divided does (400 mg twice daily) with meals for a minimum of 7 days, dependant on response. In limited studies, a course of 3 days has also been found to be adequate.

For patients weighing less than 60 kg the dose is 15mg/kg/day given in divided doses according to the dosage schedule listed above.

Appropriate steroid, antihistamine and/or anticonvulsant therapy should be administered as required. Oral or intravenous corticosteroids are recommended to prevent cerebral hypertensive episodes during the first week of treatment.

There is information suggesting individuals not responding to one course may benefit from a second course, and that the second course may result in cure. A two-week drug-free interval should be maintained between courses.

15mg/kg/day given in 2 divided doses

Route of admnistration

Oral

Defined daily dose

15 - 15 mg per kg of body weight

Dosage regimen

From 7.5 To 7.5 mg per kg of body weight 2 time(s) per day every day for 7 day(s)

Detailed description

For patients weighing less than 60 kg the dose is 15mg/kg/day given in divided doses according to the dosage schedule listed above.

Appropriate steroid, antihistamine and/or anticonvulsant therapy should be administered as required. Oral or intravenous corticosteroids are recommended to prevent cerebral hypertensive episodes during the first week of treatment.

There is information suggesting individuals not responding to one course may benefit from a second course, and that the second course may result in cure. A two-week drug-free interval should be maintained between courses.

Dosage considerations

Should be taken with meal.

Active ingredient

Albendazole

Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules.

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