Active Ingredient: Flumazenil
Flumazenil is indicated for the complete or partial reversal of the central sedative effects of benzodiazepines. It may therefore be used in the intensive care in the following situations:
For this indication, competent medicine agencies globally authorize below treatments:
Intravenous
0.2 - 1 mg
From 0.05 To 0.25 mg 4 time(s) per day every day
The recommended starting dose is 300 micrograms administered intravenously. If the required level of consciousness is not obtained within 60 seconds, a further dose of 100 micrograms can be injected and repeated at 60-second intervals, up to a total dose of 2000 micrograms or until the patient awakes.
If drowsiness recurs, a second bolus injection of flumazenil may be administered. An intravenous infusion of 100 – 400 micrograms/hour may be useful.
The dosage and rate of infusion should be adjusted individually to achieve the desired level of consciousness.
If a significant improvement in consciousness or respiratory function is not obtained after repeated doses of flumazenil, a non-benzodiazepine aetiology must be assumed.
Infusion should be discontinued every 6 hours to verify whether re-sedation occurs.
To avoid withdrawal symptoms in patients treated for a long period of time with high doses of benzodiazepines in the intensive care unit, the dosage of flumazenil has to be titrated individually and the injection has to be administered slowly.
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