Indication for Midazolam

Population group: Suitable for both men and women, only adults (18 - 65 years old)

As an intramuscular premedication for patients with physical status ASA I-IV who are to undergo surgical procedures.

For this indication, competent medicine agencies globally authorize below treatments:

0.07-0.10 mg/kg

Route of admnistration


Defined daily dose

0.07 - 0.1 mg per kg of body weight

Dosage regimen

From 0.07 To 0.1 mg per kg of body weight once every day

Detailed description

A single intramuscular injection of 0.07-0.1mg/kg body-weight, administered 30-60 minutes pre-operatively, has been shown to be adequate in most cases. The usual dose is about 5mg.

Atropine or hyoscine hydrobromide may be given concomitantly, bearing in mind that hyoscine hydrobromide will enhance and prolong the sedative and amnesic effects of midazolam.

Midazolam injection can be combined with atropine or hyoscine hydrobromide in the same syringe to be given as a single intramuscular injection.

Active ingredient

Midazolam is a derivative of the imidazobenzodiazepine group. The free base is a lipophilic substance with low solubility in water. The basic nitrogen in position 2 of the imidazobenzodiazepine ring system enables the active ingredient of midazolam to form water-soluble salts with acids.

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