Postoperative pain

Active Ingredient: Sufentanil

Indication for Sufentanil

Population group: only adults (18 years old or older)

Sufentanil is indicated for the management of acute moderate to severe post-operative pain in adult patients.

For this indication, competent medicine agencies globally authorize below treatments:

15-45 ug

Route of admnistration

Sublingual

Defined daily dose

15 ug

Dosage regimen

15 ug once every day

Detailed description

Sufentanil is to be administered in a hospital setting only. Sufentanil should only be prescribed by physicians who are experienced in the management of opioid therapy, particularly opioid adverse reactions such as respiratory depression.

Sufentanil sublingual tablets are to be self-administered by the patient in response to pain using the sufentanil administration device. Sufentanil administration device is designed to deliver a single sufentanil 15 micrograms sublingual tablet, on a patient-controlled as needed basis, with a minimum of 20 minutes (lockout interval) between doses, over a period of up to 72 hours, which is the maximum recommended treatment duration.

Dosage considerations

The dispensed sublingual tablet should dissolve under the tongue and should not be crushed, chewed, or swallowed. Patients should not eat or drink and minimize talking for 10 minutes after each dose of sufentanil.

The maximum amount of sublingual sufentanil that can be delivered via the sufentanil administration device over an hour is 45 micrograms (3 doses).

In the event of repeated maximal usage by the patient, one cartridge will last for a period of 13 hours 20 minutes. Additional sufentanil cartridges may be utilized if needed.

Active ingredient

Sufentanil

Sufentanil is a synthetic opioid analgesic drug approximately 5 to 10 times as potent as its parent drug, fentanyl, and 500 times as potent as morphine. Structurally, sufentanil differs from fentanyl through the addition of a methoxymethyl group on the piperidine ring (which is believed to reduce duration of action), and the replacement of the phenyl ring by thiophene. The main use of this medication is in operating suites and critical care where pain relief is required for a short period of time. It also offers properties of sedation and this makes it a good analgesic component of anesthetic regimen during an operation

Read more about Sufentanil

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