Active Ingredient: Bemiparin
The treatment of established deep vein thrombosis, with or without pulmonary embolism, during the acute phase.
For this indication, competent medicine agencies globally authorize below treatments:
Subcutaneous
5,000 - 25,000 [iU]
From 5,000 To 25,000 [iU] once every day
Bemiparin 25,000 IU should be administered by the subcutaneous route at a dose of 115 IU anti-Xa/kg weight, once daily. The recommended duration of treatment is 7±2 days. The daily dose generally corresponds – depending on the body weight range – to the following doses and volumes of the product in prefilled syringes: <50 kg, 0.2 ml (5,000 IU antiXa); 50-70 kg, 0.3 ml (7,500 IU anti-Xa), >70 kg, 0.4 ml (10,000 IU anti-Xa). In patients weighing more than 100 kg body-weight, the dose should be calculated on the basis of 115 IU anti-Xa/kg/day, where the concentration of anti-Xa is 25,000 IU/ml.
In the absence of any contra-indication, oral anticoagulation should be commenced 3-5 days after beginning bemiparin 25,000 IU first administration, and the dose adjusted so as to keep the International Normalized Ratio (INR) value between 2-3 times the control value. Bemiparin administration can be stopped as soon as the said INR value is achieved. Oral anticoagulation should be continued for at least 3 months.
When bemiparin is administered subcutaneously, the injection should be given in the subcutaneous cell tissue of the anterolateral or posterolateral abdominal waist, alternately on the left and right sides. The needle should be fully inserted, perpendicularly and not tangentially, into the thick part of a skin fold held between the thumb and the forefinger, the skin fold should be held throughout the whole injection. Do not rub the injection site.
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