Acute coronary syndrome

Active Ingredient: Enoxaparin

Indication for Enoxaparin

Population group: only elderly (65 years old or older)
Therapeutic intent: Curative procedure

Acute coronary syndrome:

  • Treatment of unstable angina and Non ST-segment elevation myocardial infarction (NSTEMI), in combination with oral acetylsalicylic acid.
  • Treatment of acute ST-segment elevation myocardial infarction (STEMI) including patients to be managed medically or with subsequent percutaneous coronary intervention (PCI).

For this indication, competent medicine agencies globally authorize below treatments:

75 IU/kg (0.75 mg/kg) SC every 12 hours

For:

Dosage regimens

Regimen A

Subcutaneous, 75 international units enoxaparin per kilogram of body weight, once every 12 hours.

Regimen B

Subcutaneous, 0.75 milligrams enoxaparin per kilogram of body weight, once every 12 hours.

Detailed description

For treatment of acute STEMI in elderly patients ≥75 years of age, an initial IV bolus must not be used. Initiate dosing with 75 IU/kg (0.75 mg/kg) SC every 12 hours (maximum 7,500 IU (75 mg) for each of the first two SC doses only, followed by 75 IU/kg (0.75 mg/kg) SC dosing for the remaining doses).

Dosage considerations

Injection should be made preferably when the patient is lying down. Enoxaparin sodium is administered by deep SC injection.

The administration should be alternated between the left and right anterolateral or posterolateral abdominal wall.

The whole length of the needle should be introduced vertically into a skin fold gently held between the thumb and index finger. The skin fold should not be released until the injection is complete. After administration, the injection site should not be rubbed.

Active ingredient

Enoxaparin

Enoxaparin is a LMWH with a mean molecular weight of approximately 4,500 daltons, in which the antithrombotic and anticoagulant activities of standard heparin have been dissociated. The active substance is the sodium salt.

Read more about Enoxaparin

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