Chronic hyperuricaemia

Active Ingredient: Febuxostat

Indication for Febuxostat

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Treatment of chronic hyperuricaemia in conditions where urate deposition has already occurred (including a history, or presence of, tophus and/or gouty arthritis).

For this indication, competent medicine agencies globally authorize below treatments:

80-120 mg once daily

For:

Dosage regimens

Oral, between 80 milligrams febuxostat and 120 milligrams febuxostat, once daily.

Detailed description

The recommended oral dose is 80 mg once daily without regard to food. If serum uric acid is >6 mg/dL (357 μmol/L) after 2-4 weeks, 120 mg once daily may be considered.

Febuxostat works sufficiently quickly to allow retesting of the serum uric acid after 2 weeks. The therapeutic target is to decrease and maintain serum uric acid below 6 mg/dL (357 μmol/L).

Gout flare prophylaxis of at least 6 months is recommended.

Dosage considerations

Febuxostat can be taken with or without food.

Active ingredient

Febuxostat

Uric acid is the end product of purine metabolism in humans and is generated in the cascade of hypoxanthine → xanthine → uric acid. Both steps in the above transformations are catalyzed by xanthine oxidase (XO). Febuxostat is a 2-arylthiazole derivative that achieves its therapeutic effect of decreasing serum uric acid by selectively inhibiting XO.

Read more about Febuxostat

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