Non-cystic fibrosis bronchiectasis (NCFB)

Active Ingredient: Brensocatib

Indication for Brensocatib

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Curative procedure

Brensocatib is indicated for the treatment of non-cystic fibrosis bronchiectasis (NCFB) in patients 12 years of age and older with two or more exacerbations in the prior 12 months.

For this indication, competent medicine agencies globally authorize below treatments:

25 mg once daily

For:

Dosage regimens

Oral, 25 milligrams brensocatib, once daily.

Detailed description

Η συνιστώμενη δόση είναι 25 mg από στόματος μία φορά ημερησίως με ή χωρίς τροφή.

Παράλειψη δόσης

Οι ασθενείς που παραλείπουν μια δόση θα πρέπει να λαμβάνουν την επόμενη δόση κατά τη συνήθη ώρα την επόμενη ημέρα. Οι ασθενείς δεν θα πρέπει να διπλασιάζουν τη δόση για να αναπληρώσουν τη δόση που παραλείφθηκε.

Ηλικιωμένοι

Δεν απαιτείται προσαρμογή της δόσης για τους ηλικιωμένους ασθενείς.

Active ingredient

Brensocatib

Brensocatib is a competitive and reversible inhibitor of dipeptidyl peptidase 1 (DPP1). DPP1 activates pro-inflammatory neutrophil serine proteases (NSPs) during neutrophil maturation in the bone marrow. Brensocatib reduces the activity of NSPs implicated in the pathogenesis of bronchiectasis, including neutrophil elastase, cathepsin G and proteinase 3.

Read more about Brensocatib

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