Rheumatoid arthritis

Active Ingredient: Etanercept

Indication for Etanercept

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Etanercept in combination with methotrexate is indicated for the treatment of moderate to severe active rheumatoid arthritis in adults when the response to disease-modifying antirheumatic drugs, including methotrexate (unless contraindicated), has been inadequate.

Etanercept can be given as monotherapy in case of intolerance to methotrexate or when continued treatment with methotrexate is inappropriate.

Etanercept is also indicated in the treatment of severe, active and progressive rheumatoid arthritis in adults not previously treated with methotrexate.

Etanercept, alone or in combination with methotrexate, has been shown to reduce the rate of progression of joint damage as measured by X-ray and to improve physical function.

For this indication, competent medicine agencies globally authorize below treatments:

25 mg twice weekly or 50 mg once weekly

For:

Dosage regimens

Regimen A: Subcutaneous, 25 milligrams etanercept, 2 times weekly.

Regimen B: Subcutaneous, 50 milligrams etanercept, once weekly.

Detailed description

25 mg etanercept administered twice weekly is the recommended dose. Alternatively, 50 mg administered once weekly has been shown to be safe and effective.

Available data suggest that a clinical response is usually achieved within 12 weeks of treatment. Continued therapy should be carefully reconsidered in a patient not responding within this time period.

Active ingredient

Etanercept

Etanercept is a competitive inhibitor of TNF binding to its cell surface receptors, and thereby inhibits the biological activity of TNF. The mechanism of action of etanercept is thought to be its competitive inhibition of TNF binding to cell surface TNFR, preventing TNF-mediated cellular responses by rendering TNF biologically inactive.

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