Bleeding oesophageal varices

Active Ingredient: Terlipressin

Indication for Terlipressin

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

12-24 mg in 6 divided doses daily

For:

Route of admnistration

Intravenous

Defined daily dose

12 - 24 mg

Dosage regimen

From 2 To 4 mg 6 time(s) per day every day

Loading dose

12 mg

Maintenance dose

6 mg

Detailed description

The administration of terlipressin serves the emergency care for acute bleeding oesophageal varices until endoscopic therapy is available. Afterwards the administration of terlipressin for the treatment of oesophageal varices is usually an adjuvant therapy to the endoscopic haemostasis.

Initial dose: The recommended initial dose is 1 to 2 mg terlipressin acetate# (equivalent to 5 to 10 ml of solution) administered by intravenous injection over a period of at least one minute.

Depending on the patient’s body weight the dose can be adjusted as follows:

  • weight less than 50 kg: 1 mg terlipressin acetate (5 ml).
  • weight 50kg to 70 kg: 1.5 mg terlipressin acetate (7.5 ml).
  • weight exceeding 70 kg: 2 mg terlipressin acetate (10 ml).

Maintenance dose: After the initial injection, the dose can be reduced to 1 mg terlipressin acetate every 4 to 6 hours.

# 1 to 2 mg terlipressin acetate corresponding to 0.85 to 1.7 mg terlipressin

The approximate value for the maximum daily dose of terlipressin is 120 μg/kg body weight.

The therapy is to be limited to 2–3 days in adaptation to the course of the disease.

Active ingredient

Terlipressin

Terlipressin inhibits portal hypertension with simultaneous reduction of blood circulation in portal vessels. Terlipressin contracts smooth oesophageal muscle with consecutive compression of oesophageal varices.

Read more about Terlipressin

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