Active Ingredient: Terlipressin
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous
12 - 24 mg
From 2 To 4 mg 6 time(s) per day every day
12 mg
6 mg
The administration of terlipressin serves the emergency care for acute bleeding oesophageal varices until endoscopic therapy is available. Afterwards the administration of terlipressin for the treatment of oesophageal varices is usually an adjuvant therapy to the endoscopic haemostasis.
Initial dose: The recommended initial dose is 1 to 2 mg terlipressin acetate# (equivalent to 5 to 10 ml of solution) administered by intravenous injection over a period of at least one minute.
Depending on the patient’s body weight the dose can be adjusted as follows:
Maintenance dose: After the initial injection, the dose can be reduced to 1 mg terlipressin acetate every 4 to 6 hours.
# 1 to 2 mg terlipressin acetate corresponding to 0.85 to 1.7 mg terlipressin
The approximate value for the maximum daily dose of terlipressin is 120 μg/kg body weight.
The therapy is to be limited to 2–3 days in adaptation to the course of the disease.
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