Active Ingredient: Quinagolide

Indication for Quinagolide

Population group: only adults (18 - 65 years old)

Hyperprolactinaemia (idiopathic or originating from a prolactin-secreting pituitary microadenoma or macroadenoma).

For this indication, competent medicine agencies globally authorize below treatments:

25-300 ug once daily

Route of admnistration


Defined daily dose

25 - 300 ug

Dosage regimen

From 25 To 300 ug once every day

Detailed description

The optimal dose must be titrated individually on the basis of the prolactin lowering effect and tolerability.

Treatment begins with 25 micrograms/day for the first 3 days, followed by 50 micrograms/day for a further 3 days. From day 7 onwards, the recommended dose is 75 micrograms/day.

If necessary, the daily dose may then be increased stepwise until the optimal individual response is attained. The usual maintenance dosage is 75 to 150 micrograms/day.

Daily doses of 300 micrograms or higher doses are required in less than one- third of the patients.

In such cases, the daily dosage may be increased in steps of 75 to 150 micrograms at intervals not shorter than 4 weeks until satisfactory therapeutic effectiveness is achieved or reduced tolerability, requiring the discontinuation of treatment, occurs.

Dosage considerations

It should be given only at bedtime.

Active ingredient


Quinagolide is a selective dopamine D2-receptor agonist not belonging to the chemical classes of ergot or ergoline compounds. Owing to its dopaminergic action, the drug exerts a strong inhibitory effect on the secretion of the anterior pituitary hormone prolactin, but does not reduce normal levels of other pituitary hormones.

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