Active Ingredient: Garadacimab
Garadacimab is indicated for routine prevention of recurrent attacks of hereditary angioedema (HAE) in adult and adolescent patients aged 12 years and older.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Subcutaneous, 400 milligrams garadacimab, 1 one dose. Afterwards, subcutaneous, 200 milligrams garadacimab, once monthly.
The recommended dose of garadacimab, in adults and children 12 years of age and above, is an initial loading dose of 400 mg administered subcutaneously on the first day of treatment, followed by a monthly dose of 200 mg.
Consideration should be given to discontinuing treatment in patients with normal C1-INH HAE (nC1-INH) who have shown insufficient reduction in attacks after 3 months of treatment.
Garadacimab is not intended for the treatment of acute HAE attacks.
If a dose of garadacimab is missed, the patient should be instructed to administer the dose as soon as possible.
The injection should be restricted to the following injection sites: the abdomen, the thighs and the upper outer arms. Rotation of the injection site is recommended.
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