Moderate to severe plaque psoriasis

Active Ingredient: Guselkumab

Indication for Guselkumab

Population group: only adults (18 years old or older)

Guselkumab is indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy.

For this indication, competent medicine agencies globally authorize below treatments:

100 mg at weeks 0 and 4 and a maintenance dose every 8 weeks

Route of admnistration

Subcutaneous

Defined daily dose

100 - 100 mg

Dosage regimen

From 100 To 100 mg once every 28 day(s)

Detailed description

The recommended dose of guselkumab is 100 mg by subcutaneous injection at weeks 0 and 4, followed by a maintenance dose every 8 weeks.

Consideration should be given to discontinuing treatment in patients who have shown no response after 16 weeks of treatment.

Dosage considerations

Subcutaneous use. If possible, areas of the skin that show psoriasis should be avoided as injection sites.

Active ingredient

Guselkumab
Guselkumab is a human IgG1λ monoclonal antibody (mAb) that binds selectively to the interleukin 23 (IL-23) protein with high specificity and affinity. IL-23, a regulatory cytokine, affects the differentiation, expansion, and survival of T cell subsets, (e.g., Th17 cells and Tc17 cells) and innate immune cell subsets, which represent sources of effector cytokines, including IL-17A, IL-17F and IL-22 that drive inflammatory disease. In humans, selective blockade of IL-23 was shown to normalize production of these cytokines. Read more about Guselkumab

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